Pokemon Red is based soley in the Kanto region, with no moving sprites.
Pokemon Crystal is based in Johto with the option after beating the Elite 4 to take on the Kanto gyms, the game contains moving sprites and has better graphics that Pokemon Red. There is alot more difference than that.
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It is not available in Pokemon Crystal. You will need to trade for it from Pokemon Red, Blue, or Yellow.
trade it from red,blue, or yellowMewtwo is not catchable in the wild in Pokemon Crystal.
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You cannot catch Mewtwo in Pokemon Crystal, but you can trade it from a Pokemon Red or Blue. Hope this helped :)
Squirtle is not available in Pokemon Crystal. Squirtle can only be found in Pokemon Red, Blue, or Yellow. Squirtle can be traded to Crystal from those titles.