I think pounds should be shut down because pounds are not treating animals correctly. All pounds do is capture wild animals in the woods and then they put a needle in them to kill them. It's not right. Just let the animals stay in their natural nature.
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Your game shuts down when someone (usually the Admins or the Owner) decide to shut it down for what ever reason they though fit. Also there are scripts that can shut it down or people can hack and shut it down.
It was temporarily shut down to protest SOPA and PIPA.
Yes the me2 universe website is shut down.
Yes. It has been shut down as of June 7, 2013.
Nothing Toxic has been shut down since 2011.