No it is not they are two separate stories in different timelines.
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Same graphics, same gameplay execpt in duke nukem you can look up, down, toggle run, use special utilities(jetpack),jump and duck. That's about it. I have Duke Nukem 3D and doom on my Xbox 360 and love playin them both. Doom is more serious while in Duke Nukem 3D theres humor.
No, Duke Nukem 3D uses MAP files.
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Sadly not, but you can always play the old Duke games from the playstation 1.
On default settings it would be your jump button or "A" key. Going down would be your crouch button or "Z" key.