Yes, its a remake of the original. there are some differences. for example in fire red you can access Sevii islands which have Pokemon from hoen region. there are also some small difference like Pokemon moves
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Pokemon Red was the original Pokemon game on the GameBoy along with Pokemon Blue. Pokemon FireRed is the GameBoy Advance remake that is massively updated. FireRed has all the new Pokemon introduced since Red and Blue along with new mechanics, better balancing and significantly updated graphics.
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You can not catch Sandshrew in Pokemon Firered. It is Leafgreen exclusive. Firered gets Ekans instead.
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You cannot "trade" pokemon between Pokemon FireRed and Pokemon Pearl. Instead, pokemon from Pokemon FireRed Version can be transferred to Pokemon Pearl via Pal Park.