Mewtwo is a Legendary Pokemon. No Legendary Pokemon have genders, except for Latios and Latias. Latias is a girl, and Latios is a boy.
EDIT TO THIS
I think Mewtwo is a male but it's just has a genderless ratio is all
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boy
His Snivy is a girl. And Pikachu is a boy.
a boy.
Espio is a boy
Pikachu can be either a boy or a girl however Ash's Pikachu in the TV series is a boy.