Wizards cast magic spells in every RPG, or roleplaying, game as that is an accepted standard of the class. Some RPG games this applies to are Runescape and World of Warcraft.
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Wizard101 is a MMORPG game where the players impersonate students of Wizardry. The combat system is turn-based and is similar to collectible card games. By completing quests and battling against monsters, players increase their level, learn more powerful magic spells, and explore new areas of the Spiral, the system of worlds where the game is set.
There is no such thing as a witch on The Sims 3(yet...), but you can cast spells by going on to TheSims3.com, then go to the store and buy Lady Ravendancer Goth's Book o' Spells. Then install it into your game. That way you can cast spells.
I'm asuming you mean in the game "magic the gathering". If so, then yes. Quick play spells can be used during any stage of the game.
On what game?
Wizard 101 is an online role-playing game where players become students at a wizarding school.