Basically you get the patience award after, you need to not move at all for a few seconds.
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Because of the way the quests work (sorted into five groups, with a set number picked randomly from each), and the optional nature of most quests even if you get them, you might not even fight a 'boss' encounter until you meet Archbishop Lazarus. However the first 'possible' boss is called The Butcher, and you have a 2/3 chance of being given the quest to kill him. The next possible boss is King Leoric, aka The Skeleton King, who you have a 50% chance of encountering.
The penultimate boss is the boss before the last boss.
You will find the boss after you see the all the galactic people in the heardqarters the boss will be talking. after that follow you guy up and there is the boss! gl
use foam hand, upgrade it and keep on poking the boss.
Yes, they can talk to there boss and have relations with them.