the two best ways would be to lvl. them up or use lots of HP ups.
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If you use medicine it will level it up like calcium or what you want. you can also catch legendary Pokemon and they have very high defense and hp.
It depends on how you use it - its high HP stat comes in handy sometimes.
Blissey has the most HP of all Pokemon.
There's no Pokemon with 1,000 HP. The closest to 1,000 HP is over 600-700 HP and that is Blissey.
No, there is no Pokemon that has a HP total of over 1,000. The Pokemon with the highest HP total is Blissey, which can have a maximum of 714 HP.