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You open and play them in an emulator. The best GBA emulator is Visual Boy Advance. http://vba.ngemu.com/
No, you can't because it is a GBA Rom. You can play it on the computer using a emulator. A good GBA emulator is the VisualBoyAdvance.
no, but you can play it on a different emulator called the no$gba.
To play Pokemon games on computer you have to download a emulator I would recommend these: Desmume No$gba (not for gba games) and for playing gba games: Visual Boy Advance
The best emulator is NO$GBA