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No, they could be brother and brother. Becasue Birdo IS a cross-dressing male. It even says so in the Super Mario Bros. 2 instructional manual.
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Earn +20 ptsQ: Are Yoshi and birdo brother and sister?
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Who is Yoshi's girlfriend?
Birdo
Does Yoshi know that Birdo is a boy?
fo the last time birdo is not a boy she is girl
How old is birdo?
She is 2 years younger than Yoshi.
Does Yoshi and Birdo have kids?
Yes, because in certain games you can see pink Yoshi eggs...question solved.
What game does Yoshi has a girlfriend?
Birdo is Yoshis girlfriend, and they are in multiple games together.
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