I think she gets knocked out twice.
First, she is knocked out by a punch to her jaw on the beach.
Second, Lori Westerly defeats her ina short struggle when she applies pressure to Nancy's carotid artery. She then dresses Nancy in a wetsuit while she is unconscious and transports her to a pier to dispose of her.
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In the book "Sisters in Crime," Nancy Drew is knocked out when she tries to escape from a dangerous situation involving criminals. She is hit in the head and rendered unconscious.