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They are brother and sister.
Sharpay Evans
If you mean are the actors "Lucas Grabeel" and "Ashley Tisdale" really brother and sister then no, they are not. They are definitely not brother and sister.
Troy: Zac Efron Gabriella: Vanessa Hudgens Chad: Corbin Bleu Taylor: Monique Coleman Ryan: Lucas Grabeel Sharpay: Ashley Tisdale Troy: Zac Efron Gabriella: Vanessa Hudgens Chad: Corbin Bleu Taylor: Monique Coleman Ryan: Lucas Grabeel Sharpay: Ashley Tisdale Troy: Zac Efron Gabriella: Vanessa Hudgens Chad: Corbin Bleu Taylor: Monique Coleman Ryan: Lucas Grabeel Sharpay: Ashley Tisdale Troy: Zac Efron Gabriella: Vanessa Hudgens Chad: Corbin Bleu Taylor: Monique Coleman Ryan: Lucas Grabeel Sharpay: Ashley Tisdale
Sharpay Evans is played by Ashley Tisdale.