SL is a game that you must explore on your own. I can't really give you an answer, although I can hint that You must walk bravely down a path and also have an Evil alignment. The rest is up for you to learn by yourself.
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Kimimaro's curse mark is the seal of heaven, just like Sasuke's
aired legends of bikini bottom;The monster who came to bikini bottom,Welcome to the bikini bottom triangle,The main drain,Sponge-Cano unaired legends of bikini bottom;Trenchbillies,The curse of the hex you can still watch the unaired legends if you buy the DVD Legends of bikini bottom
Because he is from branch house and all branch house members have curse seal to punish and destroy branch house member's mind. It is also to protect Byakugan from other as it seal when they die.
Sasuke loses it in his fight with Itachi when they are fighting and orochimaru emerges from Sasuke in the form of a 8 headed snake and itachi uses the sword of totsuka to seal orochimaru for all eternity along with the curse mark.
He was infected by a shinobi