It is about feeling lost and alone and wondering how you reached a certain point in your life, feeling powerless and confused. So much so that all you want is to escape. Needing someone to steer you in the right direction. Has nothing to do with out of control locomotives, or even runaway children necessarily.
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Soul Asylum
If you are referring to the Samsung with the Monster vs Aliens in it. The song is called Hey, Soul Sister by Train.
I believe it is a band called "The Cult." They wrote the original song "Sweet Soul Sister." The Cult is an English hard rock band.
Runaway - Del Shannon song - was created in 1961-02.
crazy train is harder. But it is a better song!