Krelboyne is the derogatory name the gifted class students are called in the TV show Malcolm in the Middle. The Malcolm in the Middle writers, and other uses of the Krelboyne as a name for nerds, etc. was inspired by the nerdy character Seymour Krelboyne, of Little Shop of Horrors (which was changed to Krelborn in the musical version)
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Nerd, geek, etc... possibly derived from the nerd character, Seymour Krelboyne, in Little Shop of Horrors, the term was popularized in the TV show, Malcolm in the Middle, as a name for the gifted students.