To the second generation? You mean from the very start of their lineage or from the Griffin family we know from Family Guy?
Peter & Lois Griffin then Meg, Chris & Stewie Griffin and the next generation.
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Brother Spencer
Bailey Jay is a trans porn star, born with the name Bryan Griffin. Bailey goes by the names, LineTrap, Harley Quinn, and now Bailey Jay.
Daisuke and Shina are both children of Sasuke And Sakura. They are also known as "The New Naruto Generation" Many doujinshi's that has to do with Sasuke and Sakura's kids has the names of Daisuke and Shina as there children. It is known that there is one more child, which is the youngest in the family. It is a boy but the name hasn't been revealed yet.
Wife Charlotte and sons Rob and Jonathan
In the commentary for the episode, Alex Borstein mentions that the rumour which the Griffin family spread in the episode is an actual rumour that the family guy staff decided to start in about 2000/2001. According to other people on the commentary (don't know their names) the rumour spread and My Name Is Earl then mentioned it in their show. So quick answer: I'm pretty sure it's not true