No, he isn't a direct decendant.
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well because the senju and the uzumaki clan are distance relatives
Technically, yes, they are related, though remotely, because the Uzumaki clan is distantly related to the Senju clan. Naruto's descendancy from the Uzumaki clan and Tsudnade's being the granddaughter of the First Hokage, from the Senju clan, makes them distantly related.
Naruto's grandfather is hashirama senju because kushina ( naruto's mother) is the daughter of hashirama senju. so basicly hashirama senju is naruto's grandfather.
first of all, its senju, not sinju, otherwise, remember that the namikaze isn't actually a clan, and uchiha and senju are about equal. if namikaze were a clan though, they would be strongest due to the flying thunder god technique.
naruto is from a clan called the uzamaki clan they had great fuin jutsus and were feared by some other clans or people they were almost destroyed so the uzamaki clan is spreaded out through out the ninja world and the uzamaki clan and the senju clan are very close and the same i guess they are kinda alike mostly and great friends well now lets see whats gonna happen since naruto learned how to use the nine tailed fox enjoy the manga people