Yes
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she used up too much of her chakra healing ALL the survivors from Peins attack. it took everything out ov her so she went into her state of coma
No he doesn't he was about to, but Tsunade came out of her coma, much to Kakashi's relief
She has called Tsunade: Tsunade-sama (Lady Tsunade), Hokage-sama, Godaime Hokage-sama (5th Hokage), and Shishou. (master)
Tsunade wakes up in episode 219 just when Kakashi Hatake is about to become the sixth hokage.
Tsunade doesn't bounce.