Sasuke never lost the curse mark. He does show great control over it now in shippuden and uses it as a weapon instead of a handicap though Actually it tells in manga401 that sasuke does actually get rid of the curse mark after itachi kills the remains of oorochimaru inside of sasuke. and also by killing oorochimaru sasuke was able to transform his sharingan into mangekeyo sharingan. itachi planned out sasuke whole life so that he would be safe so actually itachi was never bad he just wanted to protect sasuke and the leaf village.if u dont understand what im saying THEN READ MANGA 388-401 IT TELLS EVERY THING ABOUT THE BOND BETWEEN SASUKE AND ITACHI AND THERE IS ALSO AN EPIC FIGHT THIS IS A SPOILER BUT ONE OF THEM DIES gonna add to this: sasuke gains mangekyo by killing itachi(you probably know that already so forget the spolier thing ^^^)Yea so in exchange for orochimaru's snake abilities, which i believe sasuke has lost due to the lack of orochimaru inside of him(lolz giggidy)he gains the mangekyo...by killing itachi not orochimaru
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Yes. He gets rid of the curse mark when he fights itachi for the last time.
Kimimaro's curse mark is the seal of heaven, just like Sasuke's
Itachi removed it and killed Orochimaru during his fight with sasuke.
No. Sasuke will be freed from his curse mark when he fights Itachi. Itachi actually loves Sasuke. He had to destroy his clan because the Uchiha clan was planning to bring chaos. He killed everyone but he could not kill Sasuke. Itachi was planning to make Sasuke a great ninja, so, he acted as if he hated Sasuke so that Sasuke will train and grow stronger then himself. When Sasuke fought Itachi, Itachi was the one who released him from the curse mark. Sadly, Sasuke kills Itachi in the same battle not knowing the truth of his brother that has been lying to Sasuke all this time. Actually, Itachi seals Orochimaru with the Totsuka Blade (the blade of sealing) with Susano o' and the curse mark is gone.
Sasuke loses it in his fight with Itachi when they are fighting and orochimaru emerges from Sasuke in the form of a 8 headed snake and itachi uses the sword of totsuka to seal orochimaru for all eternity along with the curse mark.