No the Susanoo technique did not kill Itachi, Itachi was actually dying from deadly disease. He was using medicine to prolong his life so he could die Sasuke's hand. Even though Susanoo is a dangerous technique and hard on the user's body I don't believe it would kill the user from simply using it as short a time as Itachi Uchiha did.
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It would have to be Sebastian because he is a demon. He literally cannot die, or at least, cannot be killed by humans. Apparently Reapers seem to have a bit of an effect on him with their death scythes. Though Itachi is inhumanly strong, even if he were to be fast enough to kill Sebastian, Sebastian would just revive. Itachi's Susanoo and Amaterasu would probably do some massive damage to Sebastian, but I don't think Itachi would be able to torture Sebastian with his Tsukuyomi. I feel like Sebastian is incapable of being manipulated. I think the only chance Itachi would have of defeating Sebastian is by using one of the Death God jutsus where he traps Sebastian's soul. That is assuming, though, that Sebastian even HAS a soul. And it's not like Sebastian is weak anyways. He'd be able to give Itachi a good run for his money. I think in the end, Sebastian's ability to be killed and yet, not die would be the reason he would be far stronger than Itachi.
ok after sasuke kills itachi he passes out. and then madara uchiha takes sasuke to a hidden location. its almost like a cave. and during the time of sasuke healing, madara tells sasuke the truth about itachi. he tells sasuke why itachi did all the things he did. and i have seen other questions asking " is itachi a good guy " and the answer to that is yes. you see itachi killed his clan on orders of the elders of the leaf and danzo because the uchiha clan were planning to attack the hidden leaf village. and itachi was a double spy he loved the hidden leaf village and he loved his clan. but he couldn't let all of the innocent people of the hidden leaf village die by the hand of his clan. so the elders and danzo sends him to kill the entire clan. but itachi couldn't do it alone. he had the help of the famous uchiha madara. also itachi cared and loved his brother so much that he couldn't bring himself to kill him. so in the end itachi leaves the clans place and goes to see the hokage. he tells the hokage that don't tell sasuke the truth and as a last request itachi asks that sasuke is looked out for and that nothing happens to him. and then in the end when itachi and sasuke fight. itachi did and said everything as a cover up. and itachi let himself be killed by his younger brother sasuke so that he could give sasuke all his eye techniques and give sasuke that mangekyou sharingan. ( it is unclear weather sasukes sharingan is eternal or not ) so then madara tells sasuke all of this and after a long time of thinking sasuke excepts the truth and falls into a deep hatred for the hidden leaf village for making his brother do such a horrible thing. and now sasuke wants to destroy the hiddden leaf village. and his group hawk has joined akutski and madara gives sasuke itachi's eyes so while sasuke is healing from the procedure madara & kabuto created the next ninja war & i believe that is where naruto & sasuke will have there final battle oh & btw naruto is training with bee to take control of the nine tails chakra just like bee
Deidera killed himself using an explosive C2 clay jutsu in an attempt to kill Saskue Uchiha. His obsession with his "art" (C2 clay jutsu) was his own demise. As he was fighting, Saskue mocked Deidera saying the continous fight was useless because saskue would win any way. Out of anger Deidera took his strongest clay jutsu and blew up the entire area where the fight was held blowing himself up in the process but saskue escaped using a jutsu which quickly warped him out of the area, continuing on his quest which started the fight. He was searching for the murderer of his clan, his brother Itachi Uchiha. They would soon fight to the death and in the end Itachi would die as part of Itachi's master plan to ptotect Saskue. Answered by, SharpestShuriken
: Itachi died because of his over use of the Sharingan, tsukuyomi and amaterasu... He was already dying (using drugs to stay alive) until the day he meets with Sasuke. Sasuke did wound Itachi during their battle, but he did NOT kill Itachi. Itachi let Sasuke Think that he killed him. Sasuke's last jutsu did not hit Itachi in FACT it didn't even touch him.Sasuke kills him after he kills deidara from the akatsukip.s Itachi is not a bad guyLook it upyeah, after Itachi gave Sasuke his Sharigan (which he didn't even know occurred until he woke up with madara) he collapsed, Zetsu even points out that Itachi wasn't dead, he layed in the rain, blind and dying, and Sasuke collapsed next to him. Sasuke is shocked and tired and faints. I actually wondered though about the use of his sharigan it made him blind, but I'm not sure that's what made him sick--it seemed like the same symptoms Teacher and Alphonse(conquers of shambala) had in the FMA series.
Itachi was very ill before Sauske killed him. The reason why he wanted his brother to kill him was because Itachi wanted Sasuke to be the hero of the hidden leaf village. He wanted Sauake to be the one to avenge his clan. There were a few other reasons as well. Itachi wanted to battle Sasuke to rid his little brother of the cursed mark Orochimaru gave him and he also wanted to give Sasuke some of his powers before he died to protect him from Madara. During Itachi and Sasuke's fight he showed his little brother a way to obtain more power, by taking the eyes of a Uchiha to have light so he wouldn't be blinded after using his eyes too much during battle.