I don't think so. The Guaira Falls would of been the scene of the Jesuit mission in the movie, but those waterfalls were flooded in 1982, and The Mission was released in 1986. I think they moved the filming down south to the Iguazu Falls
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Bombur, and he is never the same again.
There were 40 episodes in Gravity Falls' run.
If you mean the town of Bedford Falls in the film It's a Wonderful Life, although it is fictional it is believed to be modeled on Seneca Falls in New York State. See the link below as well as Wikipedia on the movie.
No