The fruit has an odor (faintly like an orange), but is inedible for the most part. Although it is not strongly poisonous, eating it may cause vomiting. The seeds of the fruit are edible. The fruit is sometimes torn apart by squirrels to get at the seeds, but few other native animals make use of it as a food source.
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No, Osage Orange is not poisonous. You can have a reaction to any wood. I have been making and selling wooden cooking utensils made out of Osage Orange for 10 years now. My wife and I have been using them in our kitchen to cook and have never had a reaction to cooking with them. The military uniforms of world war 11 were dyed in Osage. There is not a lot of research at the present time on this wonderful wood. It really is an amazing wood.
If you will do a Google search of this wood you will find out a lot of good things about it...if you are interested in any more information or would like to find out more about my wooden kitchen utensils, please email me at, osagemann at Yahoo com Put wooden kitchen utensils in the subject line. Everything I make is guaranteed for life.