No!
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O.K. here's an for you. In an emergency situation where the cylinder has just blown and you are in an unsafe situation and cant stop for a few miles pull the spark plug wire for that cylinder and then drive slowly and carefully ( the damage is done and if its safety over a bigger repair bill go for safety first ).
Here's what happens, the crankcase will fill with gasoline vapour because the spark plug wire has been disconnected and is not igniting the gas vapour in the damaged cylinder (nor do we want the spark plug connected in that situation) and building up in the crankcase (Oil Pan).
Ultimately it's better (and less expensive for repairs) to pull over and get the car or truck towed to a garage to have it repaired. Only in a real emergency should you do as I have mentioned above and run the vehicle with the cylinder blown. Keep in mind the gas vapour will build up in the crack case and you could blow the engine right apart ( fire flames nuts bolts bits and pieces flying everywhere ) not a good scene.
It's not recommended. You won't be able to maintain a proper rate of speed on the road, highway, uphill or on a downgrade. The engine will have a tendency to stall and shut down and will not respond instantaneously when you need it to. The condition will progressively get worse and affect the engine's timing. All the power of your car starts with the cylinders, if they fail the car fails.
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