The left ventricle, it works the hardest and needs the most muscle mass.
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The left ventricle, being responsible for pumping the blood through the systemic circulation, generates the highest pressures. For this reason, the left ventricle has the thickest muscular walls.
The Left Ventricle has the thickest walls! The left ventricular myocardium is much thicker then the right ventricular myocardium because the left ventricle pumps blood into the aorta which takes blood to the rest of the body. (larger pressure gradient)
Right ventricals
Blood vessels are composed of three layers of tissue: tunica externa, tunica media, and tunica interna. The middle layer, tunica media, is composed of smooth muscle and is thickest in arteries because they need to accommodate the higher pressures created by the heart's pumping action which distributes blood throughout the body.
The thickest walled vessels are arteries, as they have to endure a more forceful power, as the heart, pumps the blood with great force around the body.