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Cortical irritability is when an increase of beta activity and corresponding over-activation is seen in areas associated with areas of epileptic focus and is associated with hallucinations. Sometimes the increase of beta-activity can be visualized as spindling beta rhythms which can be recognized as cortical irritability, epilepsy, toxic encephalopathies and is mostly seen around the waxing and waning spindles over the effected cortex.

I do not think that cortical irritability has anything to do with eating disorders, but people with eating disorders are usually irritable, but outside of that I haven't the foggiest.

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