This reaction generates NAD+ from NADH. You need NAD+ for glycolysis, so this conversion (pyruvate to lactate) regenerates one of the reactants needed for glycolysis to continue. You're usually taught that NADH is a source of energy, so getting rid of it when you are energy starved seems counterintuitive. However, when no oxygen is available, you can't use NADH as a source of energy because the electron transport chain is out of commission without oxygen.
1. Glucose is metabolised to form pyruvate (glycolysis) Anaerobic (without oxygen): - Pyruvate is converted to lactate or ethanol Aerobic (in the presence of oxygen): - Pyruvate is converted to acetyl CoA - Citric Acid Cycle - Electron transport chain
lactic acid
acetyl CoA
Normally glucose is converted to two pyruvate molecules which are then oxidized in the Krebs cycle. Since oxygen is required for this step the pyruvate accumulates and is converted to lactate. In the body lactate is can be converted to glucose in the liver and in some other tissues.What happens is that pyruvate can accept these Hs. By accepting these Hs, pyruvate becomes Lactic Acid and the co-enzymes are freed to return to glycolysis to pick up more hydrogen's, glucose continues to provide energy anaerobically
Lactate accumulates because of the lack of available oxygen in the muscles. In anaerobic conditions, the pyruvate produced by glycolysis is reduced to lactate via lactate dehydrogenase (while also oxidizing a single molecule of NADH to regenerate NAD+). NAD+ is a very important molecule and must readily be available in the cytoplasm in order for glycolysis to proceed.
lactate
The lactate is taken to the liver and converted back to pyruvate.
1. Glucose is metabolised to form pyruvate (glycolysis) Anaerobic (without oxygen): - Pyruvate is converted to lactate or ethanol Aerobic (in the presence of oxygen): - Pyruvate is converted to acetyl CoA - Citric Acid Cycle - Electron transport chain
lactic acid
acetyl CoA
Normally glucose is converted to two pyruvate molecules which are then oxidized in the Krebs cycle. Since oxygen is required for this step the pyruvate accumulates and is converted to lactate. In the body lactate is can be converted to glucose in the liver and in some other tissues.What happens is that pyruvate can accept these Hs. By accepting these Hs, pyruvate becomes Lactic Acid and the co-enzymes are freed to return to glycolysis to pick up more hydrogen's, glucose continues to provide energy anaerobically
If oxygen is present it is converted to Acetyl-CoA and enters citric acid cycle If oxygen is not present is will become lactic acid and /or ethanol
Diffrences between anaerobic and aerobic fermentation is aerobic occurs in the presence of oxygen and 2 molecules of adenisine triphosphate while anaerobic is in the absence of oxygen and produces 34 molecules of adenosine triphosphate. Lemme tell you all that there is no fermentation which is aerobic. In fact its will be wrong to classify fermentation process into aerobic and anaerobic. Its the respiration which can be aerobic or anaerobic.
Lactate accumulates because of the lack of available oxygen in the muscles. In anaerobic conditions, the pyruvate produced by glycolysis is reduced to lactate via lactate dehydrogenase (while also oxidizing a single molecule of NADH to regenerate NAD+). NAD+ is a very important molecule and must readily be available in the cytoplasm in order for glycolysis to proceed.
Lactate
Lactate and this step gain NAD+
If enough oxygen is available, the product of glycolysis, pyruvate, will be further broken down to CO2 and water. This requires oxygen and occurs partly in the mitochondrion. If not enough oxygen is available, the pyruvate will be converted to lactic acid, which causes muscular pain. This pathway also produces less energy for the cell.