Creon makes his way to the horses and burns the prophecy with his flaming sword.
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The conflict that rages in Macbeth after he hears the witches prophecy is if he has to take some action to make the prediction true or if it's all up to fate. When he hears Duncan say that Malcolm is to become the next king he knows he has to take action for the prophecy to come true.
That it starts up Creon's reversal process and that it foreshadows Creon's downfall is the significance of Teiresias' prophecy against Creon in "Antigone" by Sophocles (495 B.C.E. - 405 B.C.E.).Specifically, Teiresias the blind prophet sets in motion what no one else can. He prophesies that what goes around in Thebes will come back around to Creon and his family. Creon is so upset that he reverses his policy of non-burial of the disloyal Theban dead and Antigone's death sentence.
Oedipus accuses Creon of plotting to take his place as king.
When Creon and the audience learn of Haemon and Eurydice's suicide. This is the falling action/conclusion of what Creon's decree and his actions have entailed.
Oedipus is outraged at Tiresias' prophecy. He thinks Tiresias is lying to him and was "put up" to telling him that by Creon. Oedipus is so furious with Tiresias, that in the process he pushes Tiresias into making another prophecy (more of a premonition) that Oedipus will be blind.