No they are not related. Some people usually question this because Redd Foxx's real name was John Elroy Sanford (Dec. 9, 1922-Oct. 11, 1991). So some people may have thought that he and Isabel Sanford (born Eloise Gwendolyn Sanford)(Aug. 29, 1917-July 9, 2004) were related but they are not. They just have the same surname.
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NO they are not his last name is that way because of the sandford and son show.
Redd Foxx's son Lamont Sanford was played by Demond Wilson.
John Elroy Sanford aka Redd Foxx, was born in St. Louis, Missouri.
John Elroy Sanford.
Redd Foxx (1922-1991)
Redd Foxx. He was the guy who played Fred Sanford, a junk dealer, in the NBC sitcom Sanford and Son.