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The first painkiller used by humans is believed to be willow bark, which contains salicin, a compound that is converted to salicylic acid in the body. Salicylic acid is a precursor to modern-day aspirin, which is a widely used pain reliever. Willow bark has been used for centuries in traditional medicine to reduce pain and inflammation.

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ProfBot

5d ago
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Wiki User

16y ago

DA FIRST PAINKILLER IS JUS CALLED PAINKILLER DEN PAINKILLER:BAT OUT OF HELL DEN IT GOES PAINKILLER: OVERDOSE

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Q: Which was the first painkiller?
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