There are many kinds of drugs, which are designed to affect many different organs, but there is no doubt that the one organ which is most often affected by drugs is the brain.
Heart
The liver is the most important organ affected in yellow fever.
The liver.
The organ affected by bloating and gases is the stomach.
The lung is one organ that is affected.
the target organ is the part of the body that is most adversely affected by exposure to a hazardous substance
heart
The Heart
Affected by?
Nervous System
I think the first organ to be affected by alcohol is your liver.
That will vary from disease to disease and organ to organ.