Smokes often or has ever smoked? The Marijuana Policy Project claims that 100 million Americans have tried Marijuana at least once in their life. Since the US population is around 304 million people (July 08' Consensus) than aproximately one in every three people have tried it once in their life time.
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A recent government survey showed:
Marijuana is the most frequently used illegal drug in the United States. Over 83 million Americans over the age of 12 have tried marijuana at least once.
Over 12 million had used the drug in the month before the survey