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The Thompson-Center pistols can be loaded for cartridges such as the .30-30 and .45-70. As for dedicated pistol cartridges, the .44 has long since been eclipsed by other loads, such as the .50 AE, the .454 Casull, but the current most powerful commercially manufactured handgun cartridge is the .500 S&W Magnum.

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Q: What is the strongest handgun in the world?
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