Cotton production could not have been done profitably without slavery.
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Simple. Once the cotton gin was invented workers were needed to work on the plantations. Therefore, slavery happened.
Cotton gin. Cotton gin made cotton production more profitable.
Large plantation owners
The cotton gin was a significant factor in the rise of slavery. Owners needed more slaves to keep up with the production of cotton.
The abolishment of slavery can be described as a major disadvantage to the cotton production in the deep southern part of the United States. The Civil War itself was also a major disadvantage to cotton production because many plantations were burned along with the cotton crop.