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Only that they both contain a stimulant, are used to make people feel good, and are derived from South American plants starting with the letter C. (The stimulant in chocolate is caffiene, which is far less addictive or effective than cocaine.)

The Cacao plant grows beans used to make chocolate.

The Coca plant grows roots used to make cocaine, and leaves which are used to make a more mild stimulant in the form of raw leaf, candy or tea (for starters) used to combat altitude sickness in the Andes. Both root and leaf contain cocaine, though the roots are where it is concentrated and thus can be economically processed to create pure cocaine. (And yes, South American drug lords understand economics too...especially the part about markups.)

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Q: What is the relation between chocolate and cocaine?
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