There is only a subjective answer to this question. To try and be speciffc, a pistol where the breach can be locked in the closed position would be about as quiet as you can get.
An example of this would be a Thompson Center Contender single shot pistol.
Another requirement for a successfully "silent" pistol would be a subsonic cartridge. This could be either a naturally subsonic cartridge, such as the .45 ACP or 9x17mm/.380 ACP, or reduced loadings of a naturally supersonic cartridge to make it travel at subsonic speeds.
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