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Arguably the IMI Desert Eagle in .50 AE.
wrong to this day the most powerful handgun in production is the Austrian Pfeifer Zeliska it fires a .600 nitro express round ,
this is a bullet favoured by big game hunters to down large prey such as elephants and rhino.
Wrong again. The question is "What is the most powerful semi automatic pistol". The Pfeifer Zeliska is a single shotrevolver. There are some Wildey's out there that are fairly large (475 Wildey Mag) that are on par ballistic-ally with the Desert Eagle .50AE but the DE is the largest production semi auto.
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