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THC or tetrahydracannibinol is the main psychoactive ingredient in marijuana. Other cannibinoids however, contribute to it's psychoactivity. When high on pure THC, the user generally feels paranoid, and uncomfortable. This is why many patients don't like synthetic THC, marketed as Marinol. When THC is combined with other cannibinoids found in natural marijuana however, the high is much more pleasant. Keep in mind however, that highs off marijuana are very subjective.

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