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Answer taken from the article:

Costin & Hearing (2007). Human skin pigmentation: Melanocytes modulate skin color in response to stress. The Faseb Journal, 21(4), 976-994.

"Melanin biosynthesis is a complex pathway that appears in highly specialized cells, called melanocytes, within membrane-bound organelles referred to as melanosomes. Melanosomes are transferred via dendrites to surrounding keratinocytes, where they play a critical role in photoprotection. The anatomical relationship between keratinocytes and melanocytes is known as 'the epidermal melanin unit' and it has been estimated that each melanocyte is in contact with ∼40 keratinocytes in the basal and suprabasal layers."

Translated: Melanocytes produce melanin in nice little packages called, melanosomes. These melanosomes are then transferred to neighboring keratinocytes (i.e., the hair follicle) through dendrites. This is how the hair follicle gets its color, even though the actual hair follicle doesn't produce melanin itself.

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Do melanocytes work their way up to the surface like keratinocytes?

No, melanocytes do not work their way up to the surface like keratinocytes. Melanocytes are located primarily in the basal layer of the epidermis, where they produce melanin, the pigment responsible for skin color. In contrast, keratinocytes originate in the basal layer and gradually move up through the layers of the epidermis, undergoing a process of keratinization before shedding from the surface. Melanocytes remain in their position and transfer melanin to keratinocytes.


What pigment is phagocytized by keratinocytes?

Melanocytes phagocytize melanin. First, melanocytes which are present in the lowest or basal layer of the epidermis, produce the pigment melanin. The melanin forms granules called melanosomes. After the keratinocytes take up the pigment, it clusters around the keratinocyte nucleus on the superficial side. This protects the DNA in the keratinocyte nucleus from damage due to UV radiation.


What is cytocrine secretion?

Injection of secretory granules into neighboring cells Such as melanocytes injecting melanosomes to neighboring keratinocytes


Melanocytes and keratinocytes work together in protecting the skin from the UV damage when keratinocytes?

Accumulate the melanin granules on their superficial portion, forming a pigment that protects DNA from UV radiation


How do melanocytes and keratinocytes work together to protect the skin from UV?

Melanocytes and keratinocytes collaborate to protect the skin from UV radiation. Melanocytes produce melanin, a pigment that absorbs and dissipates UV rays, reducing DNA damage in skin cells. Once melanin is produced, it is transferred to keratinocytes, which are the primary cells in the outer layer of the skin. This melanin forms a protective barrier, shielding the underlying tissues from harmful UV exposure while also contributing to skin color.


What are most cells of the epidermis?

The majority of cells in the epidermis are keratinocytes. These cells produce the protein keratin, which helps the skin to form a protective barrier. Other cell types in the epidermis include melanocytes (produce melanin for skin color) and Langerhans cells (involved in immune responses).


How do melanocytes contribute to the production and distribution of melanosomes in the skin?

Melanocytes are cells in the skin that produce melanosomes, which are responsible for skin pigmentation. Melanocytes transfer melanosomes to neighboring skin cells, called keratinocytes, to distribute melanin and protect the skin from UV damage.


What cells produce keratin and melanin?

Keratinocytes or squamous cells produce keratin and Melanocytes produce melanin, pigment.


What is the layer of epidermis that has pigment-producing melanocytes?

The layer of the epidermis that has pigment-producing melanocytes is the stratum basale (basal layer). Melanocytes produce melanin, the pigment responsible for skin color, and transfer it to surrounding keratinocytes.


What are 5 types of cells in the epidermis?

Squamous cells


Pertaining to skin cells?

Skin is made up of various types of cells, including keratinocytes, melanocytes, and Langerhans cells. Keratinocytes are the most abundant and produce the protein keratin that provides strength and protection. Melanocytes produce melanin, the pigment that gives skin its color and helps protect against UV damage. Langerhans cells are part of the immune system and help protect against pathogens.


What kind of cells make up skin?

Skin is primarily composed of three types of cells: keratinocytes, melanocytes, and Langerhans cells. Keratinocytes are the most abundant, forming the protective outer layer and producing keratin, a protein that helps waterproof the skin. Melanocytes produce melanin, the pigment responsible for skin color and protection against UV radiation. Langerhans cells are part of the immune system, helping to detect and fight off pathogens.

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