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Big difference, Synthetic, generally refers to the thing itself being Synthetic, rather then Natural, whereas Man Made, refers to the process. Just because something is Man Made, does not by necessity make it Synthetic, look at all the man made mistakes in life, you wouldn't call them Synthetic Mistakes, would ya? or what about Man Made automobiles, you would call them Synthetic Transportation Vehicles would you? I mean,, cup cakes are man made, but are they Synthetic?

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Q: What is the difference between synthetic and man made?
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