There is no such distinction in the natural sciences.
All natural science operates by formulating testable hypotheses and then testing those hypotheses against observation. It does not matter whether the hypothesis concerns something that is too far away, too far past, too little or too large to observe directly: the methodology remains exactly the same in all cases.
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Operational science addresses only things that are able to be duplicated and observed in the present.
There are allot of difference but the main difference is the science is discovered while the literature is invented
nothing.
Engineer and Scientist
All science is knowledge but not all knowledge is science.