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You can find HCl suffix after many medicine contents. The difference is Tramadol HCl has a better bio availability than Tramadol, that means more portion of the medicine may be absorbed through the intestine. EXPLANATION: The stomach has an acidic environment. Tramadol HCl is a weak acid, so it will less ionize in acidic environment and only unionized molecules are absorbed through the gut. So Tramadol HCl is better at being absorbed through the gut than Tramadol.

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Q: What is the difference between Tramadol and Tramadol HCI?
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