MC gives only % of water in a substance(Low melting range substance).But LOD result is a combination of water content and other volatile organic solvents.And more over Melting range of a substance has to be considered in case of LOD. Substances whichever is having high melting point is required for LOD checking.
refer ICH chapter Q2(R1) for beter underrstsnding. Dnyaneshwar Patil
For example, if you had salt (solid) in water, that would be a soluteDissolved water is a Solvent= Salt water Solutionhope this helps, please recommend :)
LOD: Loss on drying......MC: Moisture content..... By using LOD we messures Accurate weight of the Compound... i.e..Loss of Solvents ,Moisture Present in that compound at the bellow of that compound Melting point.. MC: By using moisture content we just messures about the moisture of the compound..
LOD is that the loss throughout drying of sample as per prescribed conditions which supplies loss (presence) of all evaporating solvents together with water.It is the dry base. While water content provides the moisture present within the sample solely. It is unhydrous base.
minimum conc of the std compound in which the peak of the std get merged with noise called the LOD while LOQ is the 10 times multiple of LOD
Whichever is higher in value should be subtracted
What is LOD in pharmaceuticals? In my experience, it can mean 2 things: Level of Detection, as in how much of the drug is detected in a sample (blood, urine, etc) Line of Drug, as in this is an Oncology drug.
Lod de Maeyer has written: 'Lod' -- subject(s): Alchemists, Painters
Robin Lod was born on 1993-04-17.
Hapoel Lod F.C. was created in 1957.
Hapoel Lod F.C. was dissolved in 2013 due to financial difficulties.
Hapoel Bnei Lod F.C. was created in 198#.
Lod Airport massacre happened on 1972-05-30.
Lod Ganei Aviv Railway Station was created in 2008.