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If you include cannon in guns, the largest was the Tsar Howitzer, that had a bore diameter of 35 inches which means it is a 35 caliber cannon. (A .22 rifle has a bore diameter of .22 inches not 22 inches.) If you mean shoulder firearms, then the 4 guage shotgun may be the largest- although there were very large bore Paradox guns. In rifles, the German 20 mm antitank rifle of WW I (about .80 caliber) For sporting rifles, possibly the.700 Nitro Express.
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