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A shift is when the QC values move suddenly upward or downward from the mean and continue the same way mathematically changing the mean. This is usually seen when new reagents or quality control material has been used, when there is an issue with the instrument such as a change in internal temperature or dirty cuvettes, or when a calibration was not accurate.

A trend is when the QC values slowly move up or down from the mean and continue moving the same direction over time. This can be the case of a calibration that is failing or reagent stability issues.

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Q: What is te difference between a shift and a trend in quality control?
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