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Though both of these substances are made of an aluminosilicate framework, there are some key differences in regard to their morphologies, physical properties, and acidity. For instance silica-alumina is an amorphous material, and zeolites on the other hand are cyrstalline in nature. A key physical difference is that zeolites are typically microporous (i.e. very small pores) and silica-alumina are mesoporous (i.e. moderate sized pores). Lastly the Bronsted acid sites on zeolites have been found to significanly stronger than those on silica-alumina, due to the homogeneity of the zeolite.

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Zeolites are crystalline aluminosilicates that have a porous structure and are used as catalysts, adsorbents, and ion-exchangers. Silica-alumina, on the other hand, is a physical mixture of silicon dioxide and aluminum oxide used as catalysts in various chemical processes. While both are used in catalysis, zeolites have a more ordered and uniform structure compared to silica-alumina.

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