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Topic in general means a 'theme' or 'a subject'. The word comes from the Greek and originally referred to 'a place', though that has broadened to include the 'place' in a general thought sense. Such as 'the topic for the debate'. In science the word would essentially be synonymous with 'subject'. Examples would include the general broad fields such as Geology, Physics, etc. Narrower topics would be magnetism, or measurements. (Strictly Metrology).
A randomized controlled trial (RCT) is a type of scientific http://www.answers.com/topic/experiment most commonly used in testing the http://www.answers.com/topic/efficacy or http://www.answers.com/topic/effectiveness-1 of http://www.answers.com/topic/health-care http://www.answers.com/topic/service-economics (such as http://www.answers.com/topic/medicine-1 or http://www.answers.com/topic/nursing) or http://www.answers.com/topic/health http://www.answers.com/topic/technology (such as http://www.answers.com/topic/medication, http://www.answers.com/topic/medical-device or http://www.answers.com/topic/surgery). RCTs are also employed in other research areas, such as judicial, educational, and social research. As their name suggests, RCTs involve the http://www.answers.com/topic/randomness allocation of different interventions (treatments or conditions) to http://www.answers.com/topic/human-experimentation. As long as the http://www.answers.com/topic/statistical-power, randomization is an effective method for balancing http://www.answers.com/topic/confounding-variable http://www.answers.com/topic/covariate between treatment groups.
An explicit theme is usually stated outright by a character in the play. (APEX)
it is a subject of conversation or discussion - your speech should be confined to the topic agreed
An hypothesis is a theory based on observation and the knowledge of the topic.