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Depends- WHICH 38 caliber- and which cartridge. The .38 S&W is a relatively weak cartridge, but the .38 Special has been loaded to much higher energies. SOME .38 specials have more stopping power than SOME .380s. and vice versa. The .38 Super Auto has MUCH more power than the .380.

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Q: What has the most stopping power a 38 caliber or a 380 caliber hand gun?
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