The main affect is the carbon monoxide in cigarette smoke binds to the hemoglobin molecules in your red blood cells 40x stronger than oxygen. So, in effect, when you smoke, it reduces the amount of oxygen available to the brain. This creates the euphoric 'high' that cigarette smokers experience. In addition: The chemical nicotine has been proven to be one of the most addictive substances known, even stronger than heroin addiction.
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Smoking has been linked to lung cancer, which is the leading cause of death by cancer, second only to cardiovascular disease. Lung cancer develops rapidly and without symptoms, until it is so advanced that it is difficult to treat. The survival rate of lung cancer patients is quite low. It destroys your life as an example it clouds your brain and and it will kill you which is a horrible death.
Smoking for a long time, for many years, can lead to lung cancer. In tobacco there is a substance called nicotine which, if smoked, chewed, or snuffed, directly affects the brain. It reduces the thinking ability of an individual human being. Which can at times also affect his lungs. Throat cancer is another disease. A cancer that develops from chewing tobacco or pipe smoking is called Squamous Cell Carcinoma, and the only treatment available is surgery, so doctors cut off parts of the face and mouth in an attempt to stop it.
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Tobacco contains nicotine which enters the bloodstream, stimulating the release of a hormone called epinephrine. Epinephrine stimulates the central nervous system and this has a domino effect on increasing heart rate, respiration and blood pressure.
Smokeless tobacco users exhibited slower learning and adjustment to new requirements, more jerks, slower and more irregular movements, and less accurate overall performance compared to non-smokers.
Nicotine is a complex drug. It acts as an anti-psychotic by increasing alertness/wakefulness and affects acetycholine, adrenaline, and dopamine by raising there levels in the brain.