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Even though he had studied under the abolitionist Dr. Rush in Philadelphia, Cartwright contributed ideas and literature to those southerners who defended slavery. He is now most well-known for describing a condition he called "drapetomania", or the desire to flee from servitude. According to Cartwright, drapetomania is a mental disorder akin to alienation [madness]. He said that slaves should be kept in a submissive state and treated like children, with "care, kindness, attention, and humanity to prevent and cure them from running away."

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