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Antidiabetic drugs. Sulfonylureas (chlorpropamide [Diabinese], tolazamide [Tolinase], glipizide [Glucotrol] and others) act by increasing insulin release from the beta cells of the pancreas.
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How do sufonylureas treat diabetes?
Sulfonylureas stimulate the pancreas to release more insulin. They have been around for 60 years and are still widely prescribed. One important fact to remember about sulfonylureas is they can cause hypoglycemia.
Why sulfonylurea is not used in Type 1 DM?
Sulfonylureas stimulate the beta cells in the Islets of Langerhans to secrete insulin. In type I Diabetes Mellitus, the beta cells have been destroyed, so sulfonylureas are ineffective for treatment of hyperglycemia in these patients.
What medications are available orally for diabetes?
Depending on your type of diabetes their are different oral medications available such as Biguanides Meglitinides and sulfonylureas. You and your doctor should talk about which medication is best for you.
What are some secretagogue substances?
A secretagogue is something that causes secretion in the body. Gastrin is a secretagogue as it stimulates the production of gastric acids. Sulfonylureas are used as a diabetes medicine and aid the body in secreting insulin.
What were the first drugs prescribed for Type II diabetes?
in a class of compounds called sulfonylureas and include tolbutamide, tolazamide, acetohexamide, and chlorpropamide. Newer drugs in the same class are now available and include glyburide, glimeperide, and glipizide
What illness is Glyburide used to treat?
Glyburide is one of two oral medications, the other being metformin, used to treat type 2 diabetes. As of 2003, glyburide is the most popular class of medications known as sulfonylureas.
What drug interactions are associated with antidiabetic drugs?
sulfonylureas have a particularly long list of drug interactions.actions of oral hypoglycemic agents may be strengthened by highly protein bound drugs,including NSAIDs,salicylates,sulfonamides,chloramphenicol,coumarins, probenecid,MAOIs.beta blockers.
What is the specific term that refers to an amino acid whose lack inhibits protein synthesis?
The amino acid synthesis inhibitors is a term used to describe amino acids that lack inhibits protein synthesis. These inhibitors include the sulfonylureas, imidazolinones, and amino acid derivatives herbicide families
What types of medication are currently available for diabetes?
Insulin, Aspirin, Sulfonylureas, Pramlintide, and Biguanides are just a few of the common medications taken by those with diabetes. Which medication is needed should only be determined by the patient's doctor. The website http://www.diabetes.org/living-with-diabetes/treatment-and-care/medication/ has details on all these and more medications.
What category is sulfonylurea classified in for pregnancy?
These drugs are classified as category B in pregnancy
Examples of sulfonamides?
Commonly referred to as sulfa drugs. These contain "sulfonamide" group in their structure. Classes of drugs include; 1. Antibiotics like sulfadiazine, trimethoprim, sulfasalazine... 2. Antidiabetic drugs like glipizide, glimepiride, gliclazide... (=sulfonylureas) 3. Thiazide diuretics like hydrochlorthiazide, indapamide, metalozone... 4. Loop diuretics like frusemide, torsemide,... 5. Carbonic anhydrase inhibitor like acetazolamide... 6. COX2 inhibitors like celecoxib... Sulfa drugs are notorious for causing reactions which can even be fatal...
When does Crestor become generic?
ACTOS is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action. ACTOS decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue. Pioglitazone is a potent and highly selective agonist for peroxisome proliferator-activated receptor-gamma . A generic version of Actos has been approved by the FDA. However, this does not mean that the product will necessarily be commercially available . generic available From AUG - 12 .
